What is PBMC Therapy?

If you’ve had multiple embryo transfers that didn’t work, despite transferring good-quality embryos, you might have heard about something called PBMC (Peripheral Blood Mononuclear Cells) therapy. It’s a newer option that some fertility clinics are exploring to help with implantation, especially when the cause of failure is not clear.

PBMC therapy is designed to gently support your immune system in welcoming an embryo. It uses a small sample of your own blood, which is processed in the lab to collect special immune cells. These cells are then placed into your uterus a few days before embryo transfer. The goal is to make your uterus more “friendly” to the embryo and reduce any silent immune response that might be getting in the way of implantation.

How Is This Different from PRP?

PBMC and PRP are both made from your own blood, but they are very different treatments.

PRP stands for Platelet-Rich Plasma. It uses the platelets in your blood to release growth factors that help improve the health and thickness of the uterine lining. PRP is often used when someone’s lining is too thin or not responding well to estrogen.

PBMC, on the other hand, focuses on ...